Clearance of Pneumocystis murina infection is not dependent on MyD88

Eosinophils Contribute to Early Clearance of Pneumocystis murina Infection.

Pneumocystis pneumonia remains a common opportunistic infection in the diverse immunosuppressed population. One clear risk factor for susceptibility to Pneumocystis is a declining CD4(+) T cell count in the setting of HIV/AIDS or primary immunodeficiency. Non-HIV-infected individuals taking immunosuppressive drug regimens targeting T cell activation are also susceptible. Given the crucial role ...

Pneumocystis murina Immunity against Lung Infection with Responses Correlate with Protective STAT4-Dependent and Independent Th2

Role of type I IFNs in pulmonary complications of Pneumocystis murina infection.

Despite the advent of highly active antiretroviral therapy, pulmonary complications in AIDS are a common clinical problem. Pneumocystis jiroveci infection causes a life-threatening pneumonia, especially in individuals with CD4 T cell deficiencies as occurs in AIDS. Although Pneumocystis sp. is an extracellular fungal pathogen, CD8 T cells are the predominant lymphocyte recruited to the lung in ...

Pneumocystis Murina Infection in Immunodeficient Mice in a Closed Barrier Unit: a Case Report

Pneumocystis pneumonia is considered one of the most serious fungal respiratory infections in immunocompromised patients and animals. Molecular comparisons of various gene sequences clearly demonstrated that the single name P. carinii corresponds in fact to a complex group of eukaryotic organisms, which should be assigned to the kingdom Fungi (Edman et al., 1988; Stringer, 1996; AliouatDenis et...

B cell production of tumor necrosis factor in response to Pneumocystis murina infection in mice.

Pneumocystis species are opportunistic fungal pathogens that induce tumor necrosis factor (TNF) production by alveolar macrophages. Here we report that B cells from the draining lymph nodes as well as lung CD4(+) T cells are important producers of TNF upon Pneumocystis murina infection. To determine the importance of B cell-derived TNF in the primary response to P. murina, we generated bone mar...